Relief from glucose interference in microcin B17 biosynthesis by growth in a rotating-wall bioreactor
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چکیده
منابع مشابه
Particle Dynamics in a Rotating Wall Vessel Bioreactor
Rotating bioreactors such as the High Aspect Ratio Vessel (HARV) provide a low shear and gentle mixing environment, ideal for mammalian cell culture in 3D. The HARV is a cylindrical “disc-shaped” batch culture vessel with no internal moving parts, that rotates about a single axis. Oxygenation is provided by a permeable silicon rubber membrane, allowing the diffusion of gases to and from the med...
متن کاملIn vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites.
Microcin B17 (MccB17) is a 3.1-kDa Escherichia coli antibiotic that contains thiazole and oxazole heterocycles in a peptide backbone. MccB17 inhibits its cellular target, DNA gyrase, by trapping the enzyme in a complex that is covalently bound to double-strand cleaved DNA, in a manner similar to the well-known quinolone drugs. The identification of gyrase as the target of MccB17 provides an opp...
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Here we report on a novel thiazole/oxazole-modified microcin (TOMM) from Bacillus amyloliquefaciens FZB42, a Gram-positive soil bacterium. This organism is well known for stimulating plant growth and biosynthesizing complex small molecules that suppress the growth of bacterial and fungal plant pathogens. Like microcin B17 and streptolysin S, the TOMM from B. amyloliquefaciens FZB42 undergoes ex...
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Fluoroquinolones are very important drugs in the clinical antibacterial arsenal; their success is principally due to their mode of action: the stabilisation of a gyrase-DNA intermediate (the cleavage complex), which triggers a chain of events leading to cell death. Microcin B17 (MccB17) is a modified peptide bacterial toxin that acts by a similar mode of action, but is unfortunately unsuitable ...
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بمنظور مشخص نمودن ارتباط میان برخی از ساختارهای دستور زبان انگلیسی و میزان دشواری این ساختارها در ترجمه سولات تحقیق و فرضیات صفر بشرح ذیل مطرح گردید: 1 - آیا دانشجویان ایرانی مشکلاتی در ارتباط با سازش دستوری در ترجمه از زبان انگلیسی به زبان فارسی دارند؟ 2 - آیا رابطه ای بین فرمهای دستوری زبان انگلیسی و میزان دشواری این فرمها در ترجمه از زبان انگلیسی به زبان فارسی وجود دارد؟ فرضیه 1 : دانشجویان ...
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ژورنال
عنوان ژورنال: Letters in Applied Microbiology
سال: 2000
ISSN: 0266-8254,1472-765X
DOI: 10.1046/j.1472-765x.2000.00762.x